Marie Sallander, agronomie doktor, MSc & PhD

Expert på kost , motion och träning för hund & katt & därtill relaterade sjukdomar

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Peripheral administration of pancreatic polypeptide inhibits components of food-intake behavior in dogs

Helena Åkerberg1, Bengt Meyerson1, Marie Sallander2, Anne-Sofie Lagerstedt2, Åke Hedhammar2 & Dan Larhammar1

1Department of Neurosciences, Uppsala University, Uppsala, Sweden.

2Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.

Pancreatic polypeptide (PP) belongs to the neuropeptide Y (NPY) family of peptides and is released from pancreatic F cells postprandially. PP functions as a peptide hormone and has been associated with decreased food intake in humans and rodents. Our study describes the effects of PP on feeding behavior in dogs, whose mammalian order (Carnivora) is more distantly related to primates and rodents than these are to each other. Furthermore, obesity is becoming more prevalent in dogs which makes knowledge about their appetite regulation highly relevant. Repeated peripheral administration of physiological doses of PP (three injections of 30 pmol/kg each that were administered within 30 min) to six male beagle dogs prolonged the median time spent eating three servings of food by 19% but resulted in no reduction of food intake. In addition, PP decreased the duration of food-seeking behavior after the first serving by 71%. Thus, a physiological dose of PP seems to decrease both the appetitive and the consummatory drive in dogs.